منابع مشابه
Beyond antigens and adjuvants: formulating future vaccines.
The need to optimize vaccine potency while minimizing toxicity in healthy recipients has motivated studies of the formulation of vaccines to control how, when, and where antigens and adjuvants encounter immune cells and other cells/tissues following administration. An effective subunit vaccine must traffic to lymph nodes (LNs), activate both the innate and adaptive arms of the immune system, an...
متن کاملSalmonella Typhi Porins OmpC and OmpF Are Potent Adjuvants for T-Dependent and T-Independent Antigens
Several microbial components, such as bacterial DNA and flagellin, have been used as experimental vaccine adjuvants because of their inherent capacity to efficiently activate innate immune responses. Likewise, our previous work has shown that the major Salmonella Typhi (S. Typhi) outer membrane proteins OmpC and OmpF (porins) are highly immunogenic protective antigens that efficiently stimulate...
متن کاملAssembly and Immunological Processing of Polyelectrolyte Multilayers Composed of Antigens and Adjuvants
While biomaterials provide a platform to control the delivery of vaccines, the recently discovered intrinsic inflammatory characteristics of many polymeric carriers can also complicate rational design because the carrier itself can alter the response to other vaccine components. To address this challenge, we recently developed immune-polyelectrolyte multilayer (iPEMs) capsules electrostatically...
متن کاملLiposome-based Co-delivery of Adjuvants and Peptide Antigens: Application to the Development of Synthetic Vaccines
Introduction: Subunit vaccines represent an important aspect of modern vaccination. In this respect, the possibility to construct peptide-based vaccines is particularly appealing and peptides that e.g. mimic epitopes of pathogens, can be designed to induce well-defined monofunctional immune responses. Multi-epitopic constructs that contain epitopes from the same and/or different pathogen(s) can...
متن کاملFatty Acid-Mimetic Micelles for Dual Delivery of Antigens and Imidazoquinoline Adjuvants.
Vaccine design has undergone a shift towards the use of purified protein subunit vaccines, which offer increased safety and greater control over antigen specificity, but at the expense of immunogenicity. Here we report the development of a new polymer-based vaccine delivery platform engineered to enhance immunity through the co-delivery of protein antigens and the Toll-like receptor 7 (TLR7) ag...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of Medicine
سال: 1968
ISSN: 0035-9157
DOI: 10.1177/003591576806100101